The ACAT2 gene encodes a gatekeeper of intestinal cholesterol absorption that regulates cholesterolemia and gallstone disease
نویسندگان
چکیده
منابع مشابه
Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2.
The process of cholesterol absorption has yet to be completely defined at the molecular level. Because of its ability to esterify cholesterol for packaging into nascent chylomicrons, ACAT2 plays an important role in cholesterol absorption. However, it has been found that cholesterol absorption is not completely inhibited in ACAT2-deficient (ACAT2 KO) mice. Because ABCA1 mRNA expression was incr...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2003
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.510330335